Soft Tissue Biostimulators
Sculptra and Radiesse
If you're looking for long-term facial rejuvenation, biostimulators offer a powerful non-surgical solution. At Bellissima Med Spa by Tina, we use collagen-stimulating injectables like Sculptra and Radiesse to gradually restore volume, improve skin texture, and reduce the appearance of fine lines and laxity. These treatments work by activating your body’s natural collagen production—delivering results that build over time for a refreshed, youthful look with lasting benefits and minimal downtime.
What are soft tissue biostimulators?
ABOUT Soft tissue biostimulators
How soft tissue biostimulators work
Biostimulators are injectable treatments designed to stimulate your body’s natural collagen production. Unlike traditional dermal fillers that offer immediate volume through hyaluronic acid, biostimulators such as Sculptra and Radiesse work over time to gradually restore facial structure, improve skin firmness, and reduce signs of aging for long-lasting, natural-looking results.
Biostimulators contain compounds like poly-L-lactic acid (Sculptra) or calcium hydroxylapatite (Radiesse) that act as collagen stimulants. As the body naturally absorbs the product, it replaces the volume with its own collagen—leading to firmer, smoother skin. This process offers a gradual and subtle transformation, ideal for those seeking results that evolve naturally and last longer.
What to Expect from Dermal Filler Treatment
Treatment typically takes 30 to 60 minutes depending on the areas addressed. Mild swelling, redness, or tenderness at the injection sites is common and usually subsides within a few days. Unlike hyaluronic acid fillers, biostimulator results are not immediate; improvements become noticeable over several weeks as collagen production increases. Full effects may take 2–3 months to appear and can last up to 2 years or more. Most patients require a series of treatments for optimal results. Following all aftercare instructions is key to achieving the best outcome.

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Biostimulator treatments are generally well-tolerated. Most products, including Sculptra and Radiesse, are mixed with lidocaine, a local anesthetic that helps reduce discomfort during injection. You may feel a mild pinching, pressure, or slight stinging sensation. To make the experience even more comfortable, your provider may also apply a topical numbing cream beforehand. While pain tolerance varies from person to person, most patients describe the procedure as quick and manageable.
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Biostimulator treatments like Sculptra and Radiesse typically involve minimal downtime, but individual responses may vary. Common side effects include mild swelling, redness, bruising, or tenderness at the injection sites, which usually resolve within a few days. Because results develop gradually over time, there's no immediate dramatic change, but it’s still best to avoid major events for a few days post-treatment. Following your provider’s aftercare instructions—such as avoiding strenuous activity and massaging the treated area, if recommended—can help support optimal healing and results.
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Unlike traditional fillers, biostimulators work gradually by stimulating your body’s own collagen production. You may not see immediate results, but improvements typically begin to appear within 4 to 6 weeks and continue to develop over several months. Once full results are achieved, they can last up to 2 years or more, depending on the product used, the treatment area, and your body’s natural collagen response. A series of treatments is often recommended for optimal and longer-lasting results.
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Common side effects of biostimulators include redness, swelling, bruising, and tenderness at the injection sites. These reactions are typically mild and resolve within a few days. Because biostimulators stimulate collagen production over time, temporary firmness or small lumps may also occur as the product integrates with the tissue—these usually soften as collagen develops. Though rare, more serious risks like infection, nodule formation, or vascular events can occur. It's essential to have your treatment performed by a qualified and experienced injector and to discuss your full medical history to ensure biostimulators are appropriate for you.
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To ensure the safest and most effective treatment, follow these guidelines before your biostimulator appointment:
Arrive with clean, makeup-free skin to allow for a proper facial assessment and reduce the risk of infection.
Avoid NSAIDs (e.g., Ibuprofen, Advil), fish oil, Gingko Biloba, St. John’s Wort, and high doses of Vitamin E for at least one week prior, as these may increase the risk of bruising.
Discontinue Retin-A, Tretinoin, or other retinoids for three days before your procedure.
Avoid alcohol for 24 hours beforehand, as it can also contribute to bruising.
If you are prone to bruising, you may consider taking Arnica tablets starting one day before treatment—but always consult your healthcare provider before beginning any new supplements.
Avoid dental procedures two weeks before and after your appointment to minimize the risk of inflammation or infection.
Pregnant or breastfeeding clients are not eligible for biostimulator treatments.
Your provider may give you additional personalized instructions based on your medical history and treatment plan.
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Proper aftercare is essential to support collagen stimulation and optimize your results:
Avoid makeup for at least 12–24 hours to reduce the risk of infection.
Refrain from massaging or touching the treated areas, unless your provider instructs you to do so (e.g., with Sculptra, massage is typically recommended—5 minutes, 5 times a day, for 5 days).
Avoid lying down flat or bending over for at least 4 hours after treatment to minimize swelling and product displacement.
Sleep on your back with your head elevated for the first 24–48 hours to prevent pressure on the treated areas.
Limit physical activity and avoid strenuous exercise for 24–48 hours post-treatment. Light walking is fine.
Avoid extreme heat or cold (e.g., saunas, hot yoga, ice packs) for at least 24 hours, as this can affect the settling of the product.
No facials, massages, or skin treatments on the treated areas for at least two weeks, unless cleared by your provider.
Hydrate well and maintain a healthy lifestyle—since collagen production depends on your body’s healing response, proper hydration and nutrition can support better outcomes.
Always follow your provider’s personalized aftercare instructions for the best and safest results.
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Our experienced practitioners offer a selection of biostimulators tailored to your unique facial anatomy and aesthetic goals. During your consultation, they will review your concerns, medical history, and desired outcomes to recommend the most appropriate treatment—whether it’s restoring volume in the cheeks or temples, improving skin firmness, or enhancing jawline definition. Together, we’ll develop a personalized plan that leverages the collagen-stimulating benefits of Sculptra, Radiesse, or other options to help you achieve a natural, youthful appearance over time.
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Biostimulators offer a unique, non-surgical approach to facial rejuvenation by encouraging your body to rebuild its own collagen. Ideal for restoring lost volume, improving skin texture, and enhancing facial contours, these treatments provide natural-looking results that develop gradually and can last up to two years or more. With minimal downtime and lasting benefits, biostimulators are an excellent option for those seeking long-term, subtle facial enhancement. Contact us today to schedule a consultation and discover how biostimulators like Sculptra and Radiesse can help you achieve your aesthetic goals.